Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

doi:10.1016/j.mtbio.2023.100866

IMR OpenIR

	Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
	Liu, Leyi 1,2; Wu, Jie 1,2; Lv, Shiyu 1,2; Xu, Duoling 1,2; Li, Shujun 3; Hou, Wentao 3; Wang, Chao 1,2; Yu, Dongsheng 1,2
通讯作者	Wang, Chao(wangch373@mail.sysu.edu.cn) ; Yu, Dongsheng(yudsh@mail.sysu.edu.cn)
	2023-12-01
发表期刊	MATERIALS TODAY BIO
ISSN	2590-0064
卷号	23 页码:19
摘要	The significance of the osteogenesis-angiogenesis relationship in the healing process of bone defects has been increasingly emphasized in recent academic research. Surface topography plays a crucial role in guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling the modulation of scaffold physicochemical properties. This study involved the loading of varying quantities of UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting in the formation of hierarchical micro/nano topography named UiO-66/AHTs. The physicochemical properties of these scaffolds were subsequently characterized. Furthermore, the impact of these scaffolds on the osteogenic potential of BMSCs, the angiogenic potential of HUVECs, and their intercellular communication were investigated. The findings of this study indicated that 1/2UiO-66/AHT outperformed other groups in terms of osteogenic and angiogenic induction, as well as in promoting intercellular crosstalk by enhancing paracrine effects. These results suggest a promising biomimetic hierarchical topography design that facilitates the coupling of osteogenesis and angiogenesis.
关键词	Hierarchical topography UiO-66 Coupling of osteogenesis and angiogenesis
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Shenyang Talents program ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds) ; National Undergraduate Training Program for Innovation and Entrepreneurship
DOI	10.1016/j.mtbio.2023.100866
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82073378] ; National Natural Science Foundation of China[81974146] ; Natural Science Foundation of Guangdong Province[2021A1515012399] ; Shenyang Talents program[RC200230] ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds)[pdjh2022b0012] ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds)[pdjh2023a0004] ; National Undergraduate Training Program for Innovation and Entrepreneurship[202310824]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001135416900001
出版者	ELSEVIER
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/183231
专题	中国科学院金属研究所
通讯作者	Wang, Chao; Yu, Dongsheng
作者单位	1.Sun Yat Sen Univ, Hosp Stomatol, Guangzhou 510055, Peoples R China 2.Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Leyi,Wu, Jie,Lv, Shiyu,et al. Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis[J]. MATERIALS TODAY BIO,2023,23:19.
APA	Liu, Leyi.,Wu, Jie.,Lv, Shiyu.,Xu, Duoling.,Li, Shujun.,...&Yu, Dongsheng.(2023).Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis.MATERIALS TODAY BIO,23,19.
MLA	Liu, Leyi,et al."Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis".MATERIALS TODAY BIO 23(2023):19.