Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head

IMR OpenIR

	Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head
	Zhao, Dewei; Huang, Shibo; Lu, Faqiang; Wang, Benjie; Yang, Lei; Qin, Ling; Yang, Ke; Li, Yangde; Li, Weirong; Wang, Wei; Tian, Simiao; Zhang, Xiuzhi; Gao, Wenbin; Wang, Zongpu; Zhang, Yu; Xie, Xinhui; Wang, Jiali; Li, Junlei; zhaodewei2000@163.com; lingqin@cuhk.edu.hk
	2016
发表期刊	BIOMATERIALS
ISSN	0142-9612
卷号	81 页码:84-92
摘要	Hip-preserving surgery with vascularized bone graft implantation has been widely practiced in treating osteonecrosis of the femoral head (ONFH). However, the current approach presents a drawback, in which the implanted bone graft without screw fixation may slip or exhibit a certain degree of displacement postoperatively. This study was designed to investigate the application potential of biodegradable magnesium (Mg) screws for the fixation of vascularized bone graft in ONFH patients. Forty-eight patients were randomly divided into two groups: the Mg screw group (vascularized bone grafting fixed by Mg screws) and the control group (vascularized bone grafting without fixation). During 12 month follow-up period after surgery, treatment outcomes in patients were assessed by multiple imaging techniques including x-ray and computed tomography (CT) scanning as well as functional recovery Harris hip score (HHS). The temporal changes in serum levels of Mg, Ca, and P as well as in vivo degradation rate of Mg screws were determined. The absence of potential adverse effects induced by degradation products from Mg screws on surrounding bone tissue was validated via CT imaging analysis. HHS was significantly improved in the Mg screw group when compared to the control group. X-ray imaging analysis showed that the screw shape did not show significant alteration due to the diameter of Mg screws measured with approximate 25% reduction within 12 months post-surgically. The postoperative serum levels of Ca, Mg, and P, which are relevant for liver and kidney function, were all within normal physiological range in all patients of both groups. The use of biodegradable Mg screws may provide a promising bone graft screw fixation route in treating ONFH and present considerable potential for orthopedic applications. (C) 2015 Elsevier Ltd. All rights reserved.
部门归属	[zhao, dewei ; huang, shibo ; lu, faqiang ; wang, benjie ; yang, lei ; wang, wei ; tian, simiao ; zhang, xiuzhi ; gao, wenbin ; wang, zongpu ; zhang, yu ; li, junlei] dalian univ, affiliated zhongshan hosp, dept orthoped, 6 jiefang st, dalian 116001, peoples r china ; [qin, ling ; xie, xinhui ; wang, jiali] chinese univ hong kong, dept orthopaed & traumatol, musculoskeletal res lab, hong kong, hong kong, peoples r china ; [yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [li, yangde ; li, weirong] dongguan eontec co ltd, dongguan, peoples r china
关键词	Vascularized Bone Graft Biodegradability Mg Screw Osteonecrosis Of The Femoral Head
收录类别	sci
语种	英语
WOS记录号	WOS:000370103700008
引用统计	被引频次：238[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/75238
专题	中国科学院金属研究所
通讯作者	zhaodewei2000@163.com; lingqin@cuhk.edu.hk
推荐引用方式 GB/T 7714	Zhao, Dewei,Huang, Shibo,Lu, Faqiang,et al. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head[J]. BIOMATERIALS,2016,81:84-92.
APA	Zhao, Dewei.,Huang, Shibo.,Lu, Faqiang.,Wang, Benjie.,Yang, Lei.,...&lingqin@cuhk.edu.hk.(2016).Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.BIOMATERIALS,81,84-92.
MLA	Zhao, Dewei,et al."Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head".BIOMATERIALS 81(2016):84-92.