The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts

IMR OpenIR

	The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts
	L.; Yuan Wu, Y.; Hao, F. Y.; Yang, Z. M.; Zhang, J. S.; Yu, M.
	2015
发表期刊	Journal of Hard Tissue Biology
ISSN	1341-7649
卷号	24 期号:1 页码:37-42
摘要	The objective of this study was to investigate the possibility of silicon carbide (SiC) foam as an alternative material for porous hydroxyapatite (HA). The characters of two materials were evaluated and compared by a series of in vitro biological tests. The result of the morphology showed that SiC foam provided beneficial structure for cell migration. On the level of primary-osteoblasts proliferation measured by MTT assay and cell cycle analysis showed that the proliferation rate increased in the early stage on HA but in the advanced stage on SiC foam. There was no significant difference between the two materials on the level of cell differentiation detected by alkaline phosphatase (ALP) assay and real-time PCR. All of the results indicated that SiC foam was comparable to HA in terms of biocompatibility and bone conductivity.
部门归属	[wu, lin ; yuan, yue ; hao, fengyu] china med univ, sch stomatol, dept prosthodont, shenyang 110002, peoples r china. [yang, zhenming ; zhang, jinsong] chinese acad sci, inst met res, mat fabricat & proc div, shenyang 110016, peoples r china. [yu, meng] china med univ, dept lab anim, key lab transgenet anim res, shenyang 110002, liaoning provin, peoples r china. ; wu, l (reprint author), china med univ, sch stomatol, dept prosthodont, 117 nanjing,n st, shenyang 110002, peoples r china. ; wulin13@163.com
关键词	Biocompatibility Osteoblasts Porous Hydroxyapatite Silicon Carbide Foam Silicon-carbide Bone Hydroxyapatite
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73974
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	L.,Yuan Wu, Y.,Hao, F. Y.,et al. The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts[J]. Journal of Hard Tissue Biology,2015,24(1):37-42.
APA	L.,Yuan Wu, Y.,Hao, F. Y.,Yang, Z. M.,Zhang, J. S.,&Yu, M..(2015).The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts.Journal of Hard Tissue Biology,24(1),37-42.
MLA	L.,et al."The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts".Journal of Hard Tissue Biology 24.1(2015):37-42.