Collagen/apatite coating on 3-dimensional carbon/carbon composite

IMR OpenIR

	Collagen/apatite coating on 3-dimensional carbon/carbon composite
	S. H. Li; Z. G. Zheng; Q. Liu; J. R. de Wijn; K. de Groot
	1998
发表期刊	Journal of Biomedical Materials Research
ISSN	0021-9304
卷号	40 期号:4 页码:520-529
摘要	A three-dimensional carbon/carbon composite (3D C/C) was studied as potential bone-repairing material; its major mechanical properties were found to be closer to those of human bone than other common bone-repairing materials available. In vitro calcification tests revealed that as-received 3D C/C is almost bioinert in simulated body fluid (SBF) over an immersion period of 4 weeks. To improve the bioactivity of 3D C/C, surface modification was accomplished through two practical routes: (1) grafting with polyethylene glycol (PEG) and (2) phosphorylation and precalcification. After grafting with alpha, omega di(aminopropyl) polyethylene glycol 800 (NH2-PEG-NH2), a continuous layer of calcium phosphate was formed on the surface of 3D C/C in SBF after 4 weeks. Phosphorylated 3D C/C samples have the ability to induce apatite precipitation after precalcification in a saturated Ca(OH)(2) solution for 1 week. To speed up the coating process, a calcification solution with collagen was developed in which a collagen/apatite coating layer can be formed on 3D C/C in 9 h in ambient conditions. (C) 1998 John Wiley & Sons, Inc.
部门归属	leiden univ, biomat res grp, nl-3723 mb bilthoven, netherlands. acad sinica, inst met res, shenyang 110015, peoples r china.;li, sh (reprint author), leiden univ, biomat res grp, prof bronkhorstlaan 10, nl-3723 mb bilthoven, netherlands;li@rullf2.medfac.leidenuniv.nl
关键词	3d Carbon/carbon Composite Collagen/apatite Composite Coating Grafting Phosphorylation Calcium-phosphate Growth Cotton
URL	查看原文
WOS记录号	WOS:000073465000002
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/37705
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	S. H. Li,Z. G. Zheng,Q. Liu,et al. Collagen/apatite coating on 3-dimensional carbon/carbon composite[J]. Journal of Biomedical Materials Research,1998,40(4):520-529.
APA	S. H. Li,Z. G. Zheng,Q. Liu,J. R. de Wijn,&K. de Groot.(1998).Collagen/apatite coating on 3-dimensional carbon/carbon composite.Journal of Biomedical Materials Research,40(4),520-529.
MLA	S. H. Li,et al."Collagen/apatite coating on 3-dimensional carbon/carbon composite".Journal of Biomedical Materials Research 40.4(1998):520-529.