Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation

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	Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation
	E. L. Zhang; C. M. Zou
	2009
发表期刊	Acta Biomaterialia
ISSN	1742-7061
卷号	5 期号:5 页码:1732-1741
摘要	Porous titanium with a pore size of 150-600 mu m and a porosity of 67% was prepared by fiber sintering. The porous titanium had a complete three-dimensional (3D) interconnected structure and a high yield strength of 100 MPa. Si-substituted hydroxyapatite (Si-HA) was coated on the surface by a biomimetic process to improve the surface bioactivity. X-ray diffraction results showed that Si-HA coating was not well crystallized. New bone tissue was found in the uncoated porous titanium after 2 weeks of implantation and a significant increase (p < 0.05) in the bone ingrowth rate (BIR) was found after 4 weeks of implantation, indicating the good osteoconductivity of the porous structure. The HA-coated and Si-HA-coated porous titanium exhibited a significantly higher BIR than the uncoated titanium at all intervals, highlighting the better surface bioactivity and osteoconductivity of the HA- and Si-HA coatings. Also, the Si-HA-coated porous titanium demonstrated a significantly higher BIR than the HA-coated porous titanium, showing that silicon plays an active role in the surface bioactivity. For Si-HA-coated porous titanium, up to 90% pore area was covered by new bone tissue after 4 weeks of implantation in cortical bone. In the bone marrow cavity, the pore spaces were filled with bone marrow, displaying that the interconnected pore structure could provide a channel for body fluid. It was concluded that both the 3D interconnected pore structure and the Si-HA coating contributed to the high BIR. (c) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
部门归属	[zhang, erlin] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zhang, erlin] jiamusi univ, sch mat sci & engn, jiamusi 154007, peoples r china. [zou, chunming] harbin inst technol, sch mat sci & engn, harbin 150001, peoples r china.;zhang, el (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china;erlin.zhang@imr.ac.cn
关键词	Silicon Hydroxyapatite Porous Titanium Coating Bioactivity Calcium-phosphate Mechanical-properties Thin-films Bone Implants Coatings Ti Replacement Porosity Ingrowth
URL	查看原文
WOS记录号	WOS:000266506800037
引用统计	被引频次：61[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/32530
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	E. L. Zhang,C. M. Zou. Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation[J]. Acta Biomaterialia,2009,5(5):1732-1741.
APA	E. L. Zhang,&C. M. Zou.(2009).Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation.Acta Biomaterialia,5(5),1732-1741.
MLA	E. L. Zhang,et al."Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation".Acta Biomaterialia 5.5(2009):1732-1741.