Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants

doi:10.1016/j.jmst.2024.01.025

IMR OpenIR

	Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants
	Xu, Qian 1,2; Wang, Shuze 4; Bai, Yun 2,3; Wang, Qiang 4; Yang, Rui 2,3; Wang, Xiaohui 2,3; Li, Xiaowu 1; Zhang, Xing 2,3
通讯作者	Wang, Xiaohui(wang@imr.ac.cn) ; Li, Xiaowu(xwli@mail.neu.edu.cn) ; Zhang, Xing(xingzhang@imr.ac.cn)
	2024-10-01
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	195 页码:248-259
摘要	Ti3SiC2 ceramics exhibit excellent mechanical properties and good biocompatibility, rendering them promising bone substitutes for load-bearing conditions. However, the bone integration and osteogenic ability of Ti3SiC2 ceramics remain unclear. Herein, porous Ti3SiC2 ceramics were prepared and systematically investigated as bone scaffolds. The Ti3SiC2 scaffolds with a porosity of 62.9 % +/- 2.5 % showed high compressive strength similar to 68.12 +/- 4.33 MPa. Silicon hydroxyl groups formed on the surface of Ti3SiC2 after soaking in simulated body fluid, which played a critical role in the apatite mineralization of the scaffolds. Biomineralization of Ti3SiC2 scaffolds was found when implanted subcutaneously in the rat dorsum for 2 weeks, demonstrating good osteogenesis ability. The apatite mineralization of the Ti3SiC2 scaffold facilitated the polarization of RAW264.7 cells from M1 to M2 phenotype, which also promoted the differentiation of MC3T3-E1 cells. The porous Ti3SiC2 scaffolds improved osteointegration and bone regeneration after implantation in rabbit femoral defects. Impressively, the number of the newly formed trabeculae in the Ti3SiC2 group was three times of the control group after implantation for 8 weeks, showing excellent bone defect repair. This work demonstrates that Ti3SiC2 implants with improved biological functions likely via in -situ biomineralization are promising candidates for bone regeneration. (c) 2024 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Ti3 SiC2 scaffolds Biomineralization Macrophage polarization Bone regeneration
资助者	National Natural Science Foundation of China ; Liaoning Revitalization Talents Program
DOI	10.1016/j.jmst.2024.01.025
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52273278] ; Liaoning Revitalization Talents Program[XLYC2007112]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001230440700001
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/186412
专题	中国科学院金属研究所
通讯作者	Wang, Xiaohui; Li, Xiaowu; Zhang, Xing
作者单位	1.Northeastern Univ, Sch Mat Sci & Engn, Dept Mat Phys & Chem, Key Lab Anisotropy & Texture Mat,Minist Educ, Shenyang 110819, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 4.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Xu, Qian,Wang, Shuze,Bai, Yun,et al. Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2024,195:248-259.
APA	Xu, Qian.,Wang, Shuze.,Bai, Yun.,Wang, Qiang.,Yang, Rui.,...&Zhang, Xing.(2024).Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,195,248-259.
MLA	Xu, Qian,et al."Porous Ti3SiC2 ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 195(2024):248-259.