In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair

doi:10.1080/10667857.2024.2307846

IMR OpenIR

	In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair
	Meng, J.1; Zhang, Y.2; Yu, X.3; Jiao, J.4; Tan, L.5,7; Yu, B.6,8
通讯作者	Tan, L.(lltan@imr.ac.cn) ; Yu, B.(71000322@sdutcm.edu.cn)
	2024-12-31
发表期刊	MATERIALS TECHNOLOGY
ISSN	1066-7857
卷号	39 期号:1 页码:19
摘要	Amorphous magnesium alloys, characterised by their unique disordered structure, exhibit exceptional mechanical properties and superior corrosion resistance. This study introduced a novel biodegradable Mg-Zn-Ca amorphous alloy. Immersion and electrochemical tests revealed uniform degradation in a simulated body fluid environment. The degradation products predominantly contained zinc and oxygen. After 28 days of immersion, the alloy's structure largely remained intact, and it exhibited a minimal weight loss rate of 11.64 +/- 1.85%, indicating its excellent corrosion resistance. In addition, the homogeneous and rapid degradation of the Mg-Zn-Ca amorphous alloy in rats (the residual volume at 12 weeks was 14.94 +/- 5.05%, at least 2-3 times of the corrosion rate of immersion in vitro), thus increasing the bone volume/total volume and trabecular number. The new bone and the residual material surface showed good bone integration. Blood and organ tissue tests confirmed the in vivo biological safety. Therefore, Mg-Zn-Ca amorphous alloys have excellent potential as bone-repair materials, especially in load-bearing areas.
关键词	Mg-Zn-Ca amorphous alloy bone defects biodegradation osteogenesis
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Clinical Medical Science and Technology Innovation Program of the Jinan Science and Technology Bureau
DOI	10.1080/10667857.2024.2307846
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51971222] ; Natural Science Foundation of Shandong Province[ZR2022MH021] ; Clinical Medical Science and Technology Innovation Program of the Jinan Science and Technology Bureau[202019156]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:001154203400001
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/183977
专题	中国科学院金属研究所
通讯作者	Tan, L.; Yu, B.
作者单位	1.Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China 2.Nanjing Univ Sci & Technol, Nano & Heterogeneous Mat Ctr, Sch Mat Sci & Engn, Nanjing, Peoples R China 3.Shanghai Univ, Sch Mat Sci & Engn, Shanghai, Peoples R China 4.Shanghai Univ Med & Hlth Sci, Dept Orthoped, Jiading Dist Cent Hosp, Shanghai, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 6.Shandong Univ Tradit Chinese Med, Dept Orthopaed, Affiliated Hosp, Jinan, Peoples R China 7.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 8.Shandong Univ Tradit Chinese Med, Dept Orthopaed, Affiliated Hosp, Jinan 250014, Peoples R China
推荐引用方式 GB/T 7714	Meng, J.,Zhang, Y.,Yu, X.,et al. In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair[J]. MATERIALS TECHNOLOGY,2024,39(1):19.
APA	Meng, J.,Zhang, Y.,Yu, X.,Jiao, J.,Tan, L.,&Yu, B..(2024).In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair.MATERIALS TECHNOLOGY,39(1),19.
MLA	Meng, J.,et al."In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair".MATERIALS TECHNOLOGY 39.1(2024):19.