Cu-containing stainless steel target quorum sensing to interfere with bacterial motility

doi:10.1016/j.watres.2024.123044

IMR OpenIR

	Cu-containing stainless steel target quorum sensing to interfere with bacterial motility
	Liu, Min 1,2; Zhang, Xinrui 2; Yang, Chunguang 2,3
通讯作者	Zhang, Xinrui(xrzhang16s@imr.ac.cn) ; Yang, Chunguang(cgyang@imr.ac.cn)
	2025-04-15
发表期刊	WATER RESEARCH
ISSN	0043-1354
卷号	274 页码:13
摘要	Biofilms have been known to cause contamination of drinking water and reduce the efficiency of wastewater treatment. Despite there are many strategies about reducing surface adhesion or killing bacteria, stubborn biofilms are difficult to eradicate completely and still cause continuous contamination because of the difficulty to find comprehensive and effective targets. Here, we identify a new role for quorum sensing (QS) in regulating bacterial motility during biofilm development. We proposed a mechanism of quorum quenching (QQ) by Cucontaining stainless steel (SS), aiming to interfere bacterial motility which associated with surface-attached bacteria self-organizing into microcolonies in early biofilm and the growth and extension of developmental biofilm. A parallel cell-tracking process was conducted to extract the motility history of multiple cells on a newly colonized surface and movement trajectories of biofilm maturation in situ real-time. Results showed Cucontaining SS enhanced bacterial motility of early biofilm, therefore weakening the colonization. Moreover, the development of bacterial community self-organization was retarded by reducing "trajectory cross-over" during the mature stage. Using engineered strains with deleted QS signal, we confirmed QS played a key role in determining bacterial motility. The QQ by Cu-containing SS ultimately guided bacterial motility towards an unfavorable trend for biofilm development.
关键词	Cu-containing stainless steel Quorum sensing Motility Biofilm Reactive oxygen species
资助者	National Natural Science Foundation of China ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine ; Technology Innovation of Foshan City ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province
DOI	10.1016/j.watres.2024.123044
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52171242] ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine[202000206] ; Technology Innovation of Foshan City[2020001004942] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-49]
WOS研究方向	Engineering ; Environmental Sciences & Ecology ; Water Resources
WOS类目	Engineering, Environmental ; Environmental Sciences ; Water Resources
WOS记录号	WOS:001419527000001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/179912
专题	中国科学院金属研究所
通讯作者	Zhang, Xinrui; Yang, Chunguang
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Shenyang Clin Med Res Ctr Orthodont Dis, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Min,Zhang, Xinrui,Yang, Chunguang. Cu-containing stainless steel target quorum sensing to interfere with bacterial motility[J]. WATER RESEARCH,2025,274:13.
APA	Liu, Min,Zhang, Xinrui,&Yang, Chunguang.(2025).Cu-containing stainless steel target quorum sensing to interfere with bacterial motility.WATER RESEARCH,274,13.
MLA	Liu, Min,et al."Cu-containing stainless steel target quorum sensing to interfere with bacterial motility".WATER RESEARCH 274(2025):13.