Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material

doi:10.1016/j.jmst.2022.11.011

IMR OpenIR

	Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material
	Dou, Chenxi 1,2; Zhang, Mingyang 2,3; Ren, Dechun 2; Ji, Haibin 2; Yi, Zhe 1; Wang, Shaogang 2; Liu, Zengqian 2,3; Wang, Qiang 1; Zheng, Yufeng 4; Zhang, Zhefeng 2,3; Yang, Rui 2,5
通讯作者	Yi, Zhe(zheyi@cmu.edu.cn) ; Liu, Zengqian(zengqianliu@imr.ac.cn) ; Wang, Qiang(mfqwang@cmu.edu.cn)
	2023-05-20
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	146 页码:211-220
摘要	Mg (and Mg alloys) and Ti (and Ti alloys) are two important classes of metallic implant materials which are respectively completely degradable and non-degradable after implantation. Making composites com-posed of them offers the promise for combining their property advantages for bone repair. Here, we present a Mg-Ti composite fabricated by pressureless infiltration of pure Mg melt into 3D printed Ti scaf-fold, and demonstrate a potential of the composite for use as new partially degradable and bioactive implant materials. The composite has such architecture that the Mg and Ti phases are topologically bi-continuous and mutually interspersed in 3D space, and exhibits several advantages over its constituents, such as higher strengths than as-cast pure Mg and Ti scaffold along with lower Young's modulus than dense Ti. Additionally, the degradation of Mg phase may induce the formation and ingrowth of new bone tissues into the Ti scaffold to form mechanical interlocking between them; in this process, the Ti scaffold provides constant support and Young's modulus adaptively decreases toward that of bone. Despite the accelerated corrosion than pure Mg, the composite remains non-cytotoxic and does not cause obvious adverse reactions after implantation as revealed by in vitro and in vivo experiments. This study may offer a new possibility for combining mechanical durability and bioactivity in implant materials, and allow for customized and targeted design of the implant.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Mg-Ti composite Interpenetrating-phase architecture Implant Bioactivity Degradation Strength
资助者	National Key R&D Program of China ; National Natural Sci-ence Foundation of China ; Youth Innovation Promotion Association CAS
DOI	10.1016/j.jmst.2022.11.011
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2020YFA0710404] ; National Natural Sci-ence Foundation of China[51871216] ; National Natural Sci-ence Foundation of China[52173269] ; Youth Innovation Promotion Association CAS
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000913755000001
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/175222
专题	中国科学院金属研究所
通讯作者	Yi, Zhe; Liu, Zengqian; Wang, Qiang
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 4.Peking Univ, Sch Mat Sci & Engn, Beijing 100871, Peoples R China 5.ShanghaiTech Univ, Ctr Adapt Syst Engn, Sch Creat & Art, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Dou, Chenxi,Zhang, Mingyang,Ren, Dechun,et al. Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2023,146:211-220.
APA	Dou, Chenxi.,Zhang, Mingyang.,Ren, Dechun.,Ji, Haibin.,Yi, Zhe.,...&Yang, Rui.(2023).Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,146,211-220.
MLA	Dou, Chenxi,et al."Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 146(2023):211-220.