Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

doi:10.1016/j.jmst.2021.03.074

IMR OpenIR

	Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys
	Ren, Ling 1; Xu, Xiaohe 2; Liu, Hui 1,3; Yang, Ke 1; Qi, Xun 4
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com)
	2021-12-30
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	95 页码:237-248
摘要	To reduce the risk of implant-associated infections, we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role. However, both excessive and deficient Cu levels adversely affect human health; therefore, the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo . Moreover, the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated. The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate. The release rate maintained at a parts per billion level safe for humans; consequently, we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals.
关键词	Cu ions Kinetic Biocompatibility Titanium
资助者	National Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Startup Fundation for Docotors of Liaoning Province
DOI	10.1016/j.jmst.2021.03.074
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC110060 0] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; National Natural Science Foundation[81873918] ; Startup Fundation for Docotors of Liaoning Province[2019BS-293]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000733964500002
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/167247
专题	中国科学院金属研究所
通讯作者	Yang, Ke; Qi, Xun
作者单位	1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Ren, Ling,Xu, Xiaohe,Liu, Hui,et al. Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,95:237-248.
APA	Ren, Ling,Xu, Xiaohe,Liu, Hui,Yang, Ke,&Qi, Xun.(2021).Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,95,237-248.
MLA	Ren, Ling,et al."Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 95(2021):237-248.