An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation

doi:10.1002/adma.202103727

IMR OpenIR

	An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation
	Hou, Junyu 1; Xiao, Zuohui 2; Liu, Zengqian 3; Zhao, Hewei 1; Zhu, Yankun 3; Guo, Lin 1; Zhang, Zhefeng 3; Ritchie, Robert O.4; Wei, Yan 2; Deng, Xuliang 2
通讯作者	Guo, Lin(guolin@buaa.edu.cn) ; Ritchie, Robert O.(roritchie@lbl.gov) ; Wei, Yan(kqweiyan@bjmu.edu.cn) ; Deng, Xuliang(kqdengxuliang@bjmu.edu.cn)
	2021-09-27
发表期刊	ADVANCED MATERIALS
ISSN	0935-9648
页码	12
摘要	Progress toward developing metal implants as permanent hard-tissue substitutes requires both osteointegration to achieve load-bearing support, and energy-dissipation to prevent overload-induced bone resorption. However, in existing implants these two properties can only be achieved separately. Optimized by natural evolution, tooth-periodontal-ligaments with fiber-bundle structures can efficiently orchestrate load-bearing and energy dissipation, which make tooth-bone complexes survive extremely high occlusion loads (>300 N) for prolonged lifetimes. Here, a bioinspired peri-implant ligament with simultaneously enhanced osteointegration and energy-dissipation is presented, which is based on the periodontium-mimetic architecture of a polymer-infiltrated, amorphous, titania nanotube array. The artificial ligament not only provides exceptional osteoinductivity owing to its nanotopography and beneficial ingredients, but also produces periodontium-similar energy dissipation due to the complexity of the force transmission modes and interface sliding. The ligament increases bone-implant contact by more than 18% and simultaneously reduces the effective stress transfer from implant to peri-implant bone by approximate to 30% as compared to titanium implants, which as far as is known has not previously been achieved. It is anticipated that the concept of an artificial ligament will open new possibilities for developing high-performance implanted materials with increased lifespans.
关键词	amorphous titania nanotubes energy dissipation osteointegration tooth periodontal ligament
资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; National Youth Topnotch Talent Support Program ; Beijing Municipal Science & Technology Commission Projects ; Peking University Medicine Fund
DOI	10.1002/adma.202103727
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2020YFA0710401] ; National Key R&D Program of China[2020YFA0710403] ; National Key R&D Program of China[2020YFA0710404] ; National Key R&D Program of China[2018YFC1105301] ; National Key R&D Program of China[2018YFC1105302] ; National Key R&D Program of China[2018YFC1105304] ; National Natural Science Foundation of China[51532001] ; National Natural Science Foundation of China[51772011] ; National Natural Science Foundation of China[51802010] ; National Natural Science Foundation of China[52073008] ; National Natural Science Foundation of China[81922019] ; National Natural Science Foundation of China[51772006] ; National Natural Science Foundation of China[31670993] ; National Youth Topnotch Talent Support Program[QNBJ2019-3] ; Beijing Municipal Science & Technology Commission Projects[Z181100002018001] ; Peking University Medicine Fund[PKU2020LCXQ009]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000700091200001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/166764
专题	中国科学院金属研究所
通讯作者	Guo, Lin; Ritchie, Robert O.; Wei, Yan; Deng, Xuliang
作者单位	1.Beihang Univ, Sch Chem, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China 2.Peking Univ Sch & Hosp Stomatol, Dept Geriatr Dent, Natl Engn Lab Digital & Mat Technol Stomatol, NMPA Key Lab Dent Mat, Beijing 100081, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA
推荐引用方式 GB/T 7714	Hou, Junyu,Xiao, Zuohui,Liu, Zengqian,et al. An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation[J]. ADVANCED MATERIALS,2021:12.
APA	Hou, Junyu.,Xiao, Zuohui.,Liu, Zengqian.,Zhao, Hewei.,Zhu, Yankun.,...&Deng, Xuliang.(2021).An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation.ADVANCED MATERIALS,12.
MLA	Hou, Junyu,et al."An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation".ADVANCED MATERIALS (2021):12.