Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria

doi:10.1021/acsami.0c19655

IMR OpenIR

	Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria
	Zhang, Xinrui 1,2; Yang, Chunguang 2; Xi, Tong 2; Zhao, Jinlong 2; Yang, Ke 2
通讯作者	Yang, Chunguang(cgyang@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2021-01-20
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	13 期号:2 页码:2303-2315
摘要	Numerous studies have found that the surface topography affects the material antibacterial properties by reducing the attachment of bacteria on the surfaces without influencing the viability of the adhered cells. For Cu-bearing alloys with excellent contact-killing properties, bacterial adhesion on the surface is also accompanied by short-range interactions which regulate the toxic effects of the material surface against bacterial cells. Thus, the surface topography of Cu-bearing alloys, as an important factor dominating the exposure level of bacteria on the surfaces, should affect the subsequent contact-killing efficiency. In this work, our major focus was on the regulation mechanism of the surface features on the material-bacterial interactions. We correlated the surface properties including different surface roughnesses of Cu-bearing stainless steel (SS) with the bacterial damage pattern and attempted to clarify the role of surface roughness in mediating the contact-killing behavior of Cu-bearing SS. The results of both atomic force microscopy and scanning electron microscopy investigations showed that E. coil cells experienced the most rapid physical and mechanical damages after incubating with the diamond-polished Cu-bearing SS surface. The bacterial cells noticeably stiffened and the adhesion force significantly increased, as evidenced by force-distance curve measurements. Because of the enhanced hydrophobicity and higher surface potential of the diamond-polished surface, which strengthened the Lew is acid-base attractive forces and weakened the electrostatic barrier between the bacteria and the surface, a higher exposure surface for bacteria was generated. Furthermore, the contact-induced charge transfer, manifested by Cu ion burst release, and reactive oxygen species over expression contribute to an efficient contact-killing process.
关键词	Cu-bearing stainless steel surface roughness contact killing biomechanical performances interfacial interaction
资助者	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Shi-changxu Innovation Center for Advanced Materials
DOI	10.1021/acsami.0c19655
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51771199] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[U1906226] ; National Key Research and Development Program of China[2016YFB0300205] ; Youth Innovation Promotion Association CAS[2018221] ; Shi-changxu Innovation Center for Advanced Materials
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000612551400015
出版者	AMER CHEMICAL SOC
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/160632
专题	中国科学院金属研究所
通讯作者	Yang, Chunguang; Yang, Ke
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinrui,Yang, Chunguang,Xi, Tong,et al. Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(2):2303-2315.
APA	Zhang, Xinrui,Yang, Chunguang,Xi, Tong,Zhao, Jinlong,&Yang, Ke.(2021).Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria.ACS APPLIED MATERIALS & INTERFACES,13(2),2303-2315.
MLA	Zhang, Xinrui,et al."Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria".ACS APPLIED MATERIALS & INTERFACES 13.2(2021):2303-2315.