Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel

IMR OpenIR

	Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel
其他题名	Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel
	Gu, RuoXi; Wang, XiaoZeng; Li, Jing; Deng, Jie; Li, XingXing; Wang, Jiao
	2016-01-01
发表期刊	MILITARY MEDICAL RESEARCH
ISSN	2095-7467
卷号	3 期号:1
摘要	Background: This study evaluated the effect of omeprazole or pantoprazole on platelet reactivity in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients receiving clopidogrel.
其他摘要	Background This study evaluated the effect of omeprazole or pantoprazole on platelet reactivity in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients receiving clopidogrel. Methods Consecutive patients with NSTE-ACS ( n ?=?620) from general hospital of Shenyang Military Command were randomized to the omeprazole or pantoprazole (20mg Results There were no significant differences between both the groups in platelet response to clopidogrel at 12–24h after drug administration (54.09%?±?18.90% vs 51.62%?±?19.85%, P ?=?0.12), 72h after PCI (52.15%?±?19.45% vs 49.66%?±?20.05%, P ?=?0.18), and 30days after PCI (50.44%?±?14.54% vs 48.52%?±?15.08%, P ?=?0.17). The rate of AEs did not differ significantly between groups during the 30-day (15.2% vs 14.8%, P ?=?0.91) and 180-day (16.5% vs 14.5%, P ?=?0.50) follow-up periods after PCI. Conclusions The addition of omeprazole or pantoprazole to clopidogrel did not restrict the effect of platelet aggregation by reducing the conversion of clopidogrel. Compared with clopidogrel alone, pantoprazole-clopidogrel and omeprazole-clopidogrel combinations did not increase the incidence of adverse clinical events during 30-day and 180-day follow-up periods after PCI. Trial registration The study is registered in the National Institutes of Health website with identifier NCT01735227 . Registered 14 November 2012.
语种	英语
资助项目	[National Key Technology R&D Program in the "Twelfth Five-Year" Plan of China]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/159374
专题	中国科学院金属研究所
作者单位	Institute of Metal Research, Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Gu, RuoXi,Wang, XiaoZeng,Li, Jing,et al. Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel[J]. MILITARY MEDICAL RESEARCH,2016,3(1).
APA	Gu, RuoXi,Wang, XiaoZeng,Li, Jing,Deng, Jie,Li, XingXing,&Wang, Jiao.(2016).Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel.MILITARY MEDICAL RESEARCH,3(1).
MLA	Gu, RuoXi,et al."Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel".MILITARY MEDICAL RESEARCH 3.1(2016).